Rekombinanter SMAD4 Antikörper (AA 1-50)

Produktnummer ABIN7455159

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch SMAD4 in WB, IP, ICC, FACS und IHC (fp). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für Rekombinanter SMAD4 Antikörper (AA 1-50) (ABIN7455159)

Target: SMAD4 (SMAD Family Member 4 (SMAD4))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SMAD4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: BLR133J

Produktdetails anti-SMAD4 Antikörper

Bindungsspezifität: AA 1-50

Verwendungszweck: Rabbit anti-SMAD4 Recombinant Monoclonal Antibody [BLR133J]

Immunogen: between AA 1 and 50

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 6 μL/1 mg lysate

ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 01:01,00

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Phosphate Buffered Saline (PBS) containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu SMAD4

Target: SMAD4 (SMAD Family Member 4 (SMAD4))

Andere Bezeichnung: SMAD4

Hintergrund: Background: The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD4 forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. SMAD4 functions in the transforming growth factor-beta signaling pathway as well as the bone morphogenetic protein signaling pathway, regulating cell proliferation, angiogenesis, and increasing blood vessel hyperpermeability. [taken from NCBI Entrez Gene (Gene ID: 4089)].

Gen-ID: 4089

NCBI Accession: NP_005350

UniProt: Q13485

Pathways: Zellzyklus, Chromatin Binding, Autophagie