NPM1 Antikörper (AA 250-294)
Kurzübersicht für NPM1 Antikörper (AA 250-294) (ABIN7453525)
Target
Alle NPM1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 250-294
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Verwendungszweck
- Rabbit anti-NPM1 Antibody, Affinity Purified
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Homologie
- Rat,Bovine
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 250 and 294
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Isotyp
- IgG
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Applikationshinweise
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IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 5 - 10 μg/mg lysate
WB: Not recommended. Use rabbit anti-NPM1 antibody ABIN7452897.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))
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Andere Bezeichnung
- NPM1
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Hintergrund
- Background: Nucleophosmin (NPM1) is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53/p53 and ARF. It associates with nucleolar ribonucleoprotein structures and binds single-stranded nucleic acids. NPM1 binds ribosomes presumably to drive ribosome nuclear export. Chromosomal aberrations involving NPM1 have been identified in several types of leukemia [taken from the Universal Protein Resource (UniProt) P06748].
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Gen-ID
- 4869
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NCBI Accession
- NP_002511
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UniProt
- P06748
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Pathways
- Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Target
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