Girdin Antikörper (AA 425-475)

Produktnummer ABIN7451421

Dieses Anti-Girdin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Girdin in IP. Geeignet für Human.

Kurzübersicht für Girdin Antikörper (AA 425-475) (ABIN7451421)

Target: Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Girdin Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Produktdetails anti-Girdin Antikörper

Bindungsspezifität: AA 425-475

Verwendungszweck: Rabbit anti-CCDC88A Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 425 and 475

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: Not recommended

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu Girdin

Target: Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))

Andere Bezeichnung: CCDC88A

Hintergrund: Background: CCDC88A encodes the protein known as GIV (G alpha-interacting vesicle-associated protein) and Girdin. CCDC88A plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. CCDC88A Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. CCDC88A has also been found to be essential for the integrity of the actin cytoskeleton and for cell migration. It is required for formation of actin stress fibers and lamellipodia, and it may be involved in membrane sorting in the early endosome [taken from the Universal Protein Resource (UniProt) Q3V6T2].

Gen-ID: 55704

NCBI Accession: NP_001129069

UniProt: Q3V6T2