NFATC1 Antikörper

Produktnummer ABIN7384107

Der Kaninchen Polyklonal anti-NFATC1 Antikörper wird verwendet zum Nachweis von NFATC1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IHC.

Kurzübersicht für NFATC1 Antikörper (ABIN7384107)

Target: NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFATC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-NFATC1 Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human NFAT2 (NP_765978.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:3000 IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NFATC1

Target: NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1))

Andere Bezeichnung: NFAT2

Hintergrund: NF-ATC,NF-ATc1.2,NFAT2,NFATc,NFATC1,The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Molekulargewicht:

Observed_MW: 78 kDa

Calculated_MW: 38 kDa/74- 88 kDa/100-101 kDa

Gen-ID: 4772

UniProt: O95644

Pathways: RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung