NFATC1 Antikörper (AA 20-300)

Produktnummer ABIN3022101

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-NFATC1 Antikörper wird verwendet zum Nachweis von NFATC1 in Proben von Human. Er wurde validiert für WB, IHC und IF.

Kurzübersicht für NFATC1 Antikörper (AA 20-300) (ABIN3022101)

Target: NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFATC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-NFATC1 Antikörper

Bindungsspezifität: AA 20-300

Sequenz: VFGRGETLGP APRAGGTMKS AEEEHYGYAS SNVSPALPLP TAHSTLPAPC HNLQTSTPGI IPPADHPSGY GAALDGGPAG YFLSSGHTRP DGAPALESPR IEITSCLGLY HNNNQFFHDV EVEDVLPSSK RSPSTATLSL PSLEAYRDPS CLSPASSLSS RSCNSEASSY ESNYSYPYAS PQTSPWQSPC VSPKTTDPEE GFPRGLGACT LLGSPRHSPS TSPRASVTEE SWLGARSSRP ASPCNKRKYS LNGRQPPYSP HHSPTPSPHG SPRVSVTDDS W

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human NFAT2 (NP_765978.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:3000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-NFATC1 Antikörper (ABIN3022101)

Dinesh, Rasool et al.: "Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated ..." in: Cytokine, Vol. 106, pp. 54-66, (2018) (PubMed).

Details zu NFATC1

Target: NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1))

Andere Bezeichnung: NFATC1

Hintergrund: The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.,NF-ATC,NF-ATc1.2,NFAT2,NFATc,NFATC1,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,MAPK-JNK Signaling Pathway,Immunology & Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,Cardiovascular,Heart,Cardiogenesis,NFATC1

Molekulargewicht: 38 kDa/74- 88 kDa/100-101 kDa

Gen-ID: 4772

UniProt: O95644

Pathways: RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung