MEK2 Antikörper

Produktnummer ABIN7383950

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MEK2 in WB, IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für MEK2 Antikörper (ABIN7383950)

Target: MEK2 (MAP2K2) (Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-MEK2 Antikörper

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human MAP2K2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-1:5000, IHC 1:100-1:300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MEK2

Target: MEK2 (MAP2K2) (Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))

Andere Bezeichnung: MAP2K2

Hintergrund: Cardiofaciocutaneous syndrome,CFC syndrome,CFC4,Dual specificity mitogen activated protein kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 2,ERK activator kinase 2,FLJ26075,MAP kinase kinase 2,map2k2,MAPK / ERK kinase 2,MAPK/ERK kinase 2,MAPKK 2,MAPKK2,MEK 2,MEK2,Microtubule associated protein kinase kinase 2,Mitogen activated protein kinase kinase 2,Mitogen activated protein kinase kinase 2 p45,MKK 2,MKK2,MP2K2,OTTHUMP00000165826,OTTHUMP00000165827,PRKMK 2,PRKMK2,The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Molekulargewicht: 44 kDa

NCBI Accession: NP_109587

UniProt: P36507

Pathways: MAPK Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling