TRADD Antikörper (AA 1-312) (Biotin)

Produktnummer ABIN7173905

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TRADD in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TRADD Antikörper (AA 1-312) (Biotin) (ABIN7173905)

Target: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRADD Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-TRADD Antikörper (Biotin)

Bindungsspezifität: AA 1-312

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein (1-312AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TRADD

Target: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Andere Bezeichnung: TRADD

Hintergrund:

Background: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Aliases: 9130005N23Rik antibody, AA930854 antibody, TNFR1 associated DEATH domain protein antibody, TNFR1-associated DEATH domain protein antibody, TNFRSF1A associated via death domain antibody, TNFRSF1A-associated via death domain antibody, tradd antibody, TRADD_HUMAN antibody, Tumor necrosis factor receptor type 1 associated DEATH domain protein antibody, Tumor necrosis factor receptor type 1-associated DEATH domain protein antibody

UniProt: Q15628

Pathways: NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Hepatitis C