SMAD4 Antikörper (AA 27-195) (HRP)

Produktnummer ABIN7160241

Der Kaninchen Polyklonal Anti-SMAD4-Antikörper wurde für ELISA validiert. Er ist geeignet, SMAD4 in Proben von Human zu detektieren.

Kurzübersicht für SMAD4 Antikörper (AA 27-195) (HRP) (ABIN7160241)

Target: SMAD4 (SMAD Family Member 4 (SMAD4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD4 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-SMAD4 Antikörper (HRP)

Bindungsspezifität: AA 27-195

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Mothers against decapentaplegic homolog 4 protein (27-195AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SMAD4

Target: SMAD4 (SMAD Family Member 4 (SMAD4))

Andere Bezeichnung: SMAD4

Hintergrund:

Background: In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5\'-GTCT/AGAC-3\') within BMP response element (BMPRE) of cardiac activating regions. Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site, required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Aliases: (Small) Mothers Against Decapentaplegic antibody, Deleted in Pancreatic Carcinoma 4 antibody, Deleted in Pancreatic Carcinoma antibody, Deleted in pancreatic carcinoma locus 4 antibody, Deletion target in pancreatic carcinoma 4 antibody, DPC 4 antibody, DPC4 antibody, hSMAD4 antibody, JIP antibody, MAD homolog 4 antibody, MAD mothers against decapentaplegic Drosophila homolog 4 antibody, MAD mothers against decapentaplegic homolog 4 antibody, MADH 4 antibody, MADH4 antibody, Med antibody, Medea antibody, Mothers against decapentaplegic homolog 4 antibody, Mothers against decapentaplegic, Drosophila, homolog of, 4 antibody, Mothers against DPP homolog 4 antibody, MYHRS antibody, OTTHUMP00000163548 antibody, SMA- and MAD-related protein 4 antibody, SMAD 4 antibody, SMAD family member 4 antibody, SMAD mothers against DPP homolog 4 antibody, SMAD4 antibody, SMAD4_HUMAN antibody

UniProt: Q13485

Pathways: Zellzyklus, Chromatin Binding, Autophagie