LRP6 Antikörper (AA 20-150)
Kurzübersicht für LRP6 Antikörper (AA 20-150) (ABIN7158577)
Target
Alle LRP6 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 20-150
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Kreuzreaktivität
- Human
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Aufreinigung
- Antigen Affinity Purified
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Immunogen
- Recombinant Human Low-density lipoprotein receptor-related protein 6 protein (20-150AA)
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Isotyp
- IgG
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Applikationshinweise
- Recommended dilution: IHC:1:20-1:200,
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
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Andere Bezeichnung
- LRP6
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Hintergrund
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Background: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Aliases: ADCAD2 antibody, C030016K15Rik antibody, Cd antibody, FLJ90062 antibody, FLJ90421 antibody, LDL receptor related protein 6 antibody, Low density lipoprotein receptor related protein 6 antibody, Low-density lipoprotein receptor-related protein 6 antibody, LRP-6 antibody, LRP6 antibody, LRP6_HUMAN antibody, OTTHUMP00000238979 antibody, OTTHUMP00000238980 antibody, OTTHUMP00000238982 antibody, STHAG7 antibody
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UniProt
- O75581
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Pathways
- WNT Signalweg, Tube Formation
Target
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