FOXO1 Antikörper (AA 1-300)

Produktnummer ABIN7153080

Der Kaninchen Polyklonal Anti-FOXO1-Antikörper wurde für WB, IHC, ELISA und IF validiert. Er ist geeignet, FOXO1 in Proben von Human zu detektieren.

Kurzübersicht für FOXO1 Antikörper (AA 1-300) (ABIN7153080)

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-FOXO1 Antikörper

Bindungsspezifität: AA 1-300

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Forkhead box protein O1 protein (1-300AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FOXO1

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Andere Bezeichnung: FOXO1

Hintergrund:

Background: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5\\\'-TT[G/A]TTTTG-3\\\' and the related Daf-16 family binding element (DBE) with consensus sequence 5\\\'-TT[G/A]TTTAC-3\\\'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

Aliases: FKH 1 antibody, FKH1 antibody, FKHR antibody, Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma) antibody, Forkhead box O1 antibody, Forkhead box protein O1 antibody, Forkhead box protein O1A antibody, Forkhead in rhabdomyosarcoma antibody, Forkhead, Drosophila, homolog of, in rhabdomyosarcoma antibody, FoxO transcription factor antibody, foxo1 antibody, FOXO1_HUMAN antibody, FOXO1A antibody, OTTHUMP00000018301 antibody

UniProt: Q12778

Pathways: PI3K-Akt Signalweg, Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling