Caspase 8 Antikörper (AA 217-374)

Produktnummer ABIN7146964

Dieses Anti-Caspase 8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Caspase 8 in WB, IHC, ELISA und IF. Geeignet für Human.

Kurzübersicht für Caspase 8 Antikörper (AA 217-374) (ABIN7146964)

Target: Caspase 8 (CASP8)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-Caspase 8 Antikörper

Bindungsspezifität: AA 217-374

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Caspase-8 protein (217-374AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:10-1:100, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Caspase 8

Target: Caspase 8 (CASP8)

Andere Bezeichnung: CASP8

Hintergrund:

Background: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

Aliases: ALPS2B antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein antibody, Apoptosis related cysteine peptidase antibody, Apoptotic cysteine protease antibody, Apoptotic protease Mch-5 antibody, Apoptotic protease Mch5 antibody, CAP 4 antibody, CAP4 antibody, CASP-8 antibody, CASP8 antibody, CASP8_HUMAN antibody, Caspase 8 antibody, Caspase 8 apoptosis related cysteine peptidase antibody, Caspase IIX antibody, Caspase-8 subunit p10 antibody, caspase8 antibody, CED 3 antibody, FADD Homologous ICE/CED3 Like Protease antibody, FADD Like ICE antibody, FADD-homologous ICE/CED-3-like protease antibody, FADD-like ICE antibody, FLICE antibody, FLJ17672 antibody, ICE-like apoptotic protease 5 antibody, MACH alpha 1/2/3 protein antibody, MACH antibody, MACH beta 1/2/3/4 protein antibody, MACH5 antibody, MCH 5 antibody, MCH5 antibody, MGC78473 antibody, MORT1 associated ced 3 homolog antibody, MORT1 associated CED3 homolog antibody, MORT1-associated CED-3 homolog antibody, OTTHUMP00000163717 antibody, OTTHUMP00000163720 antibody, OTTHUMP00000163724 antibody, OTTHUMP00000163725 antibody, OTTHUMP00000165062 antibody, OTTHUMP00000165063 antibody, OTTHUMP00000165064 antibody, OTTHUMP00000206552 antibody, OTTHUMP00000206582 antibody

UniProt: Q14790

Pathways: Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades