BIRC3 Antikörper (AA 76-245) (Biotin)

Produktnummer ABIN7145204

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BIRC3 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für BIRC3 Antikörper (AA 76-245) (Biotin) (ABIN7145204)

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BIRC3 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-BIRC3 Antikörper (Biotin)

Bindungsspezifität: AA 76-245

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Baculoviral IAP repeat-containing protein 3 protein (76-245AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BIRC3

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Andere Bezeichnung: BIRC3

Hintergrund:

Background: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

Aliases: AIP 1 antibody, AIP1 antibody, API 2 antibody, API2 antibody, Apoptosis inhibitor 2 antibody, Baculoviral IAP repeat containing 3 antibody, Baculoviral IAP repeat containing protein 3 antibody, Baculoviral IAP repeat-containing protein 3 antibody, BIRC 3 antibody, BIRC3 antibody, BIRC3_HUMAN antibody, C IAP2 antibody, C-IAP2 antibody, Cellular inhibitor of apoptosis 2 antibody, cellular inhibitor of apoptosis protein 2 antibody, CIAP 2 antibody, CIAP2 antibody, HAIP 1 antibody, HAIP1 antibody, HIAP 1 antibody, HIAP-1 antibody, HIAP1 antibody, IAP homolog C antibody, IAP-1 antibody, Inhibitor of apoptosis protein 1 antibody, MALT 2 antibody, MALT2 antibody, Mammalian IAP homolog C antibody, MIHC antibody, RING finger protein 49 antibody, RNF49 antibody, TNFR2 TRAF signaling complex protein 1 antibody, TNFR2 TRAF signalling complex protein antibody, TNFR2-TRAF-signaling complex protein 1 antibody

UniProt: Q13489

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades