MAP2K3 Antikörper (pThr222)

Produktnummer ABIN7138807

Dieses Anti-MAP2K3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MAP2K3 in WB, IHC und ELISA. Geeignet für Human.

Kurzübersicht für MAP2K3 Antikörper (pThr222) (ABIN7138807)

Target: MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2K3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-MAP2K3 Antikörper

Bindungsspezifität: pThr222

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of threonine 222(A-K-T(p)-M-D) derived from Human MAP2K3 .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MAP2K3

Target: MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

Andere Bezeichnung: MAP2K3

Hintergrund:

Background:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells.

Derijard B., Science 267:682-685(1995).
Moriguchi T., J. Biol. Chem. 271:26981-26988(1996).
The MGC Project Team, Genome Res. 14:2121-2127(2004).

Aliases: AW212142 antibody, dual specificity mitogen activated protein kinase kinase 3 antibody, Dual specificity mitogen-activated protein kinase kinase 3 antibody, MAP kinase kinase 3 antibody, map2k3 antibody, MAPK ERK kinase 3 antibody, MAPK/ERK kinase 3 antibody, MAPKK 3 antibody, MAPKK3 antibody, MEK 3 antibody, MEK3 antibody, Mitogen activated protein kinase kinase 3 antibody, MKK 3 antibody, MKK3 antibody, mMKK3b antibody, MP2K3_HUMAN antibody, PRKMK 3 antibody, PRKMK3 antibody, protein kinase, mitogen-activated, kinase 3 antibody, SAPK kinase 2 antibody, SAPKK 2 antibody, SAPKK2 antibody, Stress activated protein kinase kinase 2 antibody

UniProt: P46734

Pathways: MAPK Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagie, Signaling Events mediated by VEGFR1 and VEGFR2