PRKACA Antikörper (pThr197)

Produktnummer ABIN7138793

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PRKACA in WB, ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PRKACA Antikörper (pThr197) (ABIN7138793)

Target: PRKACA (Protein Kinase A, alpha (PRKACA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKACA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-PRKACA Antikörper

Bindungsspezifität: pThr197

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of threonine 197(R-T-W(p)-T-L) derived from Human PKA alpha/beta CAT.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PRKACA

Target: PRKACA (Protein Kinase A, alpha (PRKACA))

Andere Bezeichnung: PRKACA

Hintergrund:

Background: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Ghislaine Garrel, Endocrinology, Jun 1997, 138: 2259. W Li, Learn. Mem., Jan 1996, 2: 320 - 333. Sharmin Schauble, J. Biol. Chem., May 2007, 282: 14952 - 14959. Yong G. Wang, J. Gen. Physiol., Jan 1998, 111: 113.

Aliases: cAMP dependent protein kinase alpha catalytic subunit antibody, cAMP dependent protein kinase beta catalytic subunit antibody, cAMP dependent protein kinase catalytic beta subunit isoform 4ab antibody, cAMP dependent protein kinase catalytic subunit alpha antibody, cAMP dependent protein kinase catalytic subunit alpha, isoform 1 antibody, cAMP dependent protein kinase catalytic subunit beta antibody, cAMP-dependent protein kinase catalytic subunit alpha antibody, KAPCA_HUMAN antibody, PKA C alpha antibody, PKA C beta antibody, PKA C-alpha antibody, PKACA antibody, PKACB antibody, PPNAD4 antibody, PRKACA antibody, PRKACAA antibody, PRKACB antibody, Protein kinase A catalytic subunit alpha antibody, Protein kinase A catalytic subunit antibody, Protein kinase A catalytic subunit beta antibody, Protein kinase, cAMP dependent, catalytic, alpha antibody, Protein kinase, cAMP dependent, catalytic, beta antibody

UniProt: P17612

Pathways: NF-kappaB Signalweg, Hedgehog Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion