MAP2K7 Antikörper (pSer271)

Produktnummer ABIN7138753

Produktdetails anti-MAP2K7 Antikörper

Target: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Bindungsspezifität: pSer271

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2K7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine271(V-D-S(p)-K-A) derived from Human MAP2K7.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MAP2K7

Target: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Andere Bezeichnung: MAP2K7 (MAP2K7 Produkte)

Hintergrund:

Background:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

Wu Z., Mol. Cell. Biol. 17:7407-7416(1997).
Lu X., J. Biol. Chem. 272:24751-24754(1997).
Foltz I.N., J. Biol. Chem. 273:9344-9351(1998).

Aliases: c-Jun N-terminal kinase kinase 2 antibody, Dual specificity mitogen activated protein kinase kinase 7 antibody, Dual specificity mitogen-activated protein kinase kinase 7 antibody, JNK activating kinase 2 antibody, JNK kinase 2 antibody, JNK-activating kinase 2 antibody, JNKK 2 antibody, Jnkk-2 antibody, Jnkk2 antibody, MAP kinase kinase 7 antibody, MAP2K7 antibody, MAPK/ERK kinase 7 antibody, MAPKK 7 antibody, MAPKK-7 antibody, MAPKK7 antibody, MEK 7 antibody, Mitogen Activated Protein Kinase kinase 7 antibody, MKK 7 antibody, MKK-7 antibody, MKK7 antibody, MP2K7_HUMAN antibody, PRKMK 7 antibody, PRKMK-7 antibody, PRKMK7 antibody, SAPK kinase 4 antibody, SAPKK-4 antibody, SAPKK4 antibody, Sek 2 antibody, Sek-2 antibody, Sek2 antibody, SKK4 antibody, stress-activated protein kinase kinase 4 antibody

UniProt: O14733

Pathways: MAPK Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling