Girdin Antikörper (pSer1765)

Produktnummer ABIN7091890

Der Kaninchen Monoklonal Anti-Girdin-Antikörper wurde für IHC (p) validiert. Er ist geeignet, Girdin in Proben von Human zu detektieren.

Kurzübersicht für Girdin Antikörper (pSer1765) (ABIN7091890)

Target: Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Girdin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: G5F7

Produktdetails anti-Girdin Antikörper

Bindungsspezifität: pSer1765

Homologie: Human,Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthesised phosphopeptide derived from human APE around the phosphorylation site of Ser1765

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Girdin

Target: Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))

Andere Bezeichnung: Girdin

Hintergrund:

Synonyms: GIV (pY1765), Girdin (phospho Y1765), p-Girdin (phospho Y1765), Akt phosphorylation enhancer, APE, Coiled coil domain containing protein 88A, G alpha interacting vesicle associated protein, Girders of actin filament, GIV, HkRP1, Hook related protein 1, AKT iphosphorylation enhancer, Akt phosphorylation enhancer, Ccdc88a, GIV, GRDN, GRDN_HUMAN, HkRP1, Hook related protein 1, Hook-related protein 1, KIAA1212.

Background: This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Gen-ID: 55704

UniProt: Q3V6T2