Rekombinanter CD36 Antikörper

Produktnummer ABIN7072627

Dieses Kaninchen Chimeric-Antikörper erkennt spezifisch CD36 in FACS, IHC, IF, IP und BP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Rekombinanter CD36 Antikörper (ABIN7072627)

Target: CD36

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser CD36 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Blocking Peptide (BP)

Klon: 185-1G2 (B467)

Produktdetails anti-CD36 Antikörper

Verwendungszweck: Anti-CD36 [185-1G2 (B467)], Rabbit IgG, kappa

Spezifität: This antibody is specific against CD36. The antibody recognises an epitope between amino acids 155 - 183. CD36 is a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. It acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry as well as mediates uptake of M. fortuitum, E. coli and S. aureus.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgM

Aufreinigung: Protein A affinity purified

Immunogen: This antibody was raised by immunizing mice with stimulated human leukocytes.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody is recommended for the detection and analysis of CD36 via various methods. For instance, it was used to stain ovarian cancer tissue samples via immunohistochemistry, demonstrating that CD36 was expressed in the cytoplasm of cancer cells while stromal cells were negative (Têtu et al., 2008). Furthermore, 185-1G2 antibody was shown to precipitate CD36 from a platelate lysate sample (Miao et al., 2001). Finally, this antibody has also blocking properties against CD36 and has been widely used to inhibit this receptor (Short et al., 2005).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgM format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD36

Target: CD36

Andere Bezeichnung: CD36

Hintergrund: SRB1, Scavenger receptor class B member 1, CD36 and LIMPII analogous 1, CLA-1, CD36 antigen-like 1, Collagen type I receptor, thrombospondin receptor-like 1, SR-BI

UniProt: Q8WTV0

Pathways: TLR Signalweg, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteine