Patched 1 Antikörper

Produktnummer ABIN7255007

Der Kaninchen Polyklonal Anti-Patched 1-Antikörper wurde für IHC und IF validiert. Er ist geeignet, Patched 1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Patched 1 Antikörper (ABIN7255007)

Target: Patched 1 (PTCH1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Patched 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Patched 1 Antikörper

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human PTCH1 (NP_000255.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:100 IF 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Patched 1

Target: Patched 1 (PTCH1)

Andere Bezeichnung: PTCH1

Hintergrund: This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Gen-ID: 5727

UniProt: Q13635

Pathways: Hedgehog Signalweg, Carbohydrate Homeostasis, Tube Formation