ULK1 Antikörper (AA 350-400)

Produktnummer ABIN6991858

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ULK1 in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für ULK1 Antikörper (AA 350-400) (ABIN6991858)

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ULK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ULK1 Antikörper

Bindungsspezifität: AA 350-400

Spezifität: Two alternatively spliced transcript variants encoding different isoforms have been identified. ULK1 antibody is predicted to not cross-react with ULK2.

Aufreinigung: ULK1 Antibody is affinity chromatography purified via peptide column.

Immunogen: ULK1 antibody was raised against a 16 amino acid peptide near the center of human ULK1 . The immunogen is located within amino acids 350 - 400 of ULK1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ULK1 Antibody can be used for detection of ULK1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ULK1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ULK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu ULK1

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Andere Bezeichnung: ULK1

Hintergrund: ULK1 Antibody: ULK1, also known as ATG1, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK1 results in a severe defect in the autophagy pathway. ULK1 is highly conserved among eukaryotes, and are the Unc-51-like kinases, ULK1 and ULK2 in mammals. ULK1 is ubiquitously expressed and involved in autophagy in response to starvation. It is the target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13. ULK1 also plays a role early in neuronal differentiation.

Molekulargewicht: Predicted: 116 kDa

Observed: 105 kDa

Gen-ID: 8408

NCBI Accession: NP_003556

UniProt: O75385

Pathways: Regulation of Cell Size, Autophagie