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FOXO1 Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-FOXO1-Antikörper wurde für WB, ELISA, IF und ICC validiert. Er ist geeignet, FOXO1 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN6991358

Kurzübersicht für FOXO1 Antikörper (N-Term) (ABIN6991358)

Target

Alle FOXO1 Antikörper anzeigen
FOXO1 (Forkhead Box O1 (FOXO1))

Reaktivität

  • 238
  • 175
  • 152
  • 48
  • 30
  • 25
  • 18
  • 11
  • 9
  • 8
  • 8
  • 4
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 218
  • 27
  • 1
Kaninchen

Klonalität

  • 206
  • 40
Polyklonal

Konjugat

  • 120
  • 10
  • 9
  • 8
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
Dieser FOXO1 Antikörper ist unkonjugiert

Applikation

  • 201
  • 91
  • 78
  • 74
  • 65
  • 58
  • 44
  • 37
  • 26
  • 20
  • 13
  • 6
  • 6
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 28
    • 21
    • 20
    • 18
    • 17
    • 16
    • 16
    • 16
    • 10
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Aufreinigung

    FOXO1 Antibody is affinity chromatography purified via peptide column.

    Immunogen

    FOXO1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human FOXO1. The immunogen is located within the first 50 amino acids of FOXO1.

    Isotyp

    IgG
  • Applikationshinweise

    FOXO1 antibody can be used for detection of FOXO1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 4 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    FOXO1 Antibody is supplied in PBS containing 0.02 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,4 °C

    Informationen zur Lagerung

    FOXO1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target

    FOXO1 (Forkhead Box O1 (FOXO1))

    Andere Bezeichnung

    FOXO1

    Hintergrund

    FOXO1 Antibody: FOXO1, also known as FKHR or ForkHead in Rhabdomyosarcoma, is a 70 kDa protein which is a ubiquitously expressed member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In insulin-responsive tissues, stress or nutrient abundance triggers phosphorylation by PKB/AKT, blocking nuclear translocation and activity. Genetic mutations involving FOXO1A are a cause of alveolar rhabdomyosarcoma (RMS2). Recent studies link the anti-tumor activity of FOXO1 and the process of autophagy.

    Gen-ID

    2308

    NCBI Accession

    NP_002006

    UniProt

    Q12778

    Pathways

    PI3K-Akt Signalweg, Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling
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