TLR4 Antikörper (C-Term)

Produktnummer ABIN6990422

Der Kaninchen Polyklonal Anti-TLR4-Antikörper wurde für ELISA und IHC (p) validiert. Er ist geeignet, TLR4 in Proben von Human zu detektieren.

Kurzübersicht für TLR4 Antikörper (C-Term) (ABIN6990422)

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TLR4 Antikörper

Bindungsspezifität: C-Term

Spezifität: TLR4 antibody is predicted to not cross-react with other TLR protein family members.

Aufreinigung: TLR4 Antibody is affinity chromatography purified via peptide column.

Immunogen: TLR4 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TLR4. The immunogen is located within the last 50 amino acids of TLR4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TLR4 antibody can be used for detection of TLR4 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TLR4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TLR4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TLR4

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Andere Bezeichnung: TLR4

Hintergrund: TLR4 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-κ,B. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

Gen-ID: 7099

NCBI Accession: NP_612564

UniProt: O00206

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteine