p21 Antikörper (AA 81-159)

Produktnummer ABIN6989051

Der Kaninchen Polyklonal Anti-p21-Antikörper wurde für IHC (p) validiert. Er ist geeignet, p21 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für p21 Antikörper (AA 81-159) (ABIN6989051)

Target: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p21 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-p21 Antikörper

Bindungsspezifität: AA 81-159

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse CDKN1A/p21

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu p21

Target: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Andere Bezeichnung: CDKN1A/p21

Hintergrund:

Synonyms: p21, P21 protein, Activating Fragment 1, CAP20, Cation chloride cotransporter-interacting protein 1, CDK Interacting Protein 1, CDK-interacting protein 1, CDKI, CDKN 1, CDKN1, CDKN1A, CIP1, Cyclin Dependent Kinase Inhibitor 1A, Cyclin-dependent kinase inhibitor 1, Cyclin-dependent kinase inhibitor 1A (P21), Cyclin-dependent kinase inhibitor 1A (p21, Cip1), DNA Synthesis Inhibitor, MDA 6, MDA-6, MDA6, Melanoma Differentiation Associated Protein 6, Melanoma differentiation-associated protein 6, Melanoma differentiation-associated protein, p21CIP1, p21WAF, PIC1, SDI1, SLC12A9, WAF1, Wildtype p53 Activating Fragment 1, Wildtype p53-activated fragment 1, CDN1A_HUMAN.

Background: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Gen-ID: 12575

UniProt: P39689

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Zellzyklus, AMPK Signaling, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagie