PRKACA Antikörper (AA 1-100) (HRP)

Produktnummer ABIN6987978

Produktdetails anti-PRKACA Antikörper (HRP)

Target: PRKACA (Protein Kinase A, alpha (PRKACA))

Bindungsspezifität: AA 1-100

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKACA Antikörper ist konjugiert mit HRP

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Sheep,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human cAMP Protein Kinase Catalytic subunit

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu PRKACA

Target: PRKACA (Protein Kinase A, alpha (PRKACA))

Andere Bezeichnung: PRKACA (PRKACA Produkte)

Synonyme: PKACA antikoerper, Calpha antikoerper, Cs-PKA antikoerper, PKCA1 antikoerper, PKA antikoerper, PKCD antikoerper, Pkaca antikoerper, zgc:158799 antikoerper, protein kinase cAMP-activated catalytic subunit alpha antikoerper, protein kinase, cAMP dependent, catalytic, alpha antikoerper, cAMP-dependent protein kinase catalytic subunit antikoerper, protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a antikoerper, PRKACA antikoerper, Prkaca antikoerper, kin-1 antikoerper, prkacaa antikoerper

Hintergrund:

Synonyms: cAMP Protein Kinase Catalytic subunit, cAMP dependent protein kinase alpha catalytic subunit, cAMP dependent protein kinase beta catalytic subunit, cAMP dependent protein kinase catalytic beta subunit isoform 4ab, cAMP dependent protein kinase catalytic subunit alpha, cAMP dependent protein kinase catalytic subunit alpha, isoform 1, cAMP dependent protein kinase catalytic subunit beta, DKFZp781I2452, MGC102831, MGC41879, MGC48865, MGC9320, PKA C alpha, PKA C beta, PKACA, PKACB, PRKACB, Protein kinase A catalytic subunit alpha, Protein kinase A catalytic subunit, Protein kinase A catalytic subunit beta, Protein kinase cAMP dependent catalytic alpha, Protein kinase cAMP dependent catalytic beta, Protein kinase, cAMP dependent, catalytic, alpha, Protein kinase, cAMP dependent, catalytic, beta.

Background: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]

Gen-ID: 5566

UniProt: P17612

Pathways: NF-kappaB Signalweg, Hedgehog Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion