TLR4 Antikörper
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- Target Alle TLR4 Antikörper anzeigen
- TLR4 (Toll-Like Receptor 4 (TLR4))
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Reaktivität
- Human, Ratte, Hund, Affe, Schwein, Meerschweinchen
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser TLR4 Antikörper ist unkonjugiert
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Applikation
- Functional Studies (Func)
- Spezifität
- This MAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
- Aufreinigung
- Purified by Protein A/G
- Immunogen
- Recombinant full-length human TLR4 protein
- Klon
- TLR4-230
- Isotyp
- IgG2a kappa
- Top Product
- Discover our top product TLR4 Primärantikörper
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- Applikationshinweise
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Positive Control: HeLa, PC12, human peripheral blood cells. Dendritic cells, macrophage and monocytes in tonsil, placenta and adrenal.
Known Application: Functional Studies (Order Ab without Azide), Optimal dilution for a specific application should be determined.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-80 °C
- Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Haltbarkeit
- 24 months
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- Target
- TLR4 (Toll-Like Receptor 4 (TLR4))
- Andere Bezeichnung
- TLR4 (TLR4 Produkte)
- Synonyme
- ARMD10 antikoerper, CD284 antikoerper, TLR-4 antikoerper, TOLL antikoerper, Lps antikoerper, Ly87 antikoerper, Ran/M1 antikoerper, Rasl2-8 antikoerper, toll like receptor 4 antikoerper, toll-like receptor 4 antikoerper, TLR4 antikoerper, Tlr4 antikoerper
- Molekulargewicht
- 95-120kDa
- Gen-ID
- 7099
- UniProt
- O00206
- Pathways
- TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteine
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