TLR4 Antikörper

Produktnummer ABIN6938587

Der Maus Monoklonal anti-TLR4 Antikörper (Klon TLR4-230) (ABIN6938587) detektiert spezifisch TLR4 in Func. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Hund, Schwein, Meerschweinchen und Affe.

Kurzübersicht für TLR4 Antikörper (ABIN6938587)

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Reaktivität: Human, Ratte, Hund, Schwein, Meerschweinchen, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TLR4 Antikörper ist unkonjugiert

Applikation: Functional Studies (Func)

Klon: TLR4-230

Produktdetails anti-TLR4 Antikörper

Verwendungszweck: CD284 (Toll-Like Receptor 4) Antibody

Spezifität: This MAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Kreuzreaktivität (Details): Human. Monkey. Pig. Dog. Rat. Guinea Pig.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human TLR4 protein

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Functional Studies (Order Ab without Azide), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, PC12, human peripheral blood cells. Dendritic cells, macrophage and monocytes in tonsil, placenta and adrenal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu TLR4

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Andere Bezeichnung: TLR4

Hintergrund:

ARMD10, CD284, hToll, TLR4, TOLL, Toll Endotoxin Hyporesponsiveness, Toll-like receptor 4

HeLa, human peripheral blood cells. Dendritic cells, macrophage and monocytes in tonsil, placenta and adrenal., PC12

Molekulargewicht: 95-120kDa

Gen-ID: 7099, 174312

UniProt: O00206

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteine