PPP3R1 Antikörper

Produktnummer ABIN6938230

Produktdetails anti-PPP3R1 Antikörper

Target: PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PPP3R1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length Calcineurin B protein

Klon: CALNB-2342

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu PPP3R1

Target: PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))

Andere Bezeichnung: PPP3R1 (PPP3R1 Produkte)

Synonyme: si:ch211-274c22.8 antikoerper, canb antikoerper, CALNB1 antikoerper, CNB antikoerper, CNB1 antikoerper, CaNB1 antikoerper, Cnb1 antikoerper, MCIP1 antikoerper, protein phosphatase 3, regulatory subunit B, alpha a antikoerper, protein phosphatase 3 regulatory subunit B, alpha S homeolog antikoerper, protein phosphatase 3 regulatory subunit B, alpha antikoerper, protein phosphatase 3, regulatory subunit B, alpha antikoerper, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) antikoerper, ppp3r1a antikoerper, ppp3r1.S antikoerper, PPP3R1 antikoerper, Ppp3r1 antikoerper

Hintergrund: Calcineurin B, type I (19 kDa), Calcineurin subunit B type 1, CALNB1, CNB1, PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform, Protein phosphatase 3 regulatory subunit B alpha, Protein phosphatase 3 regulatory subunit B alpha isoform 1,Calcineurin B / PPP3R1
Cellular localisation: Cytoplasmic and Cell Surface

Molekulargewicht: 19kDa

Gen-ID: 5534, 280604

UniProt: P63098

Pathways: RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling