MAPK14 Antikörper

Produktnummer ABIN6656051

Hersteller Produkt- Nr.: 100-401-g26

Dieses Anti-MAPK14-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MAPK14 in WB, IHC, IF und IP. Geeignet für Human.

Kurzübersicht für MAPK14 Antikörper (ABIN6656051)

Target: MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPK14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-MAPK14 Antikörper

Hersteller Produkt- Nr.: 100-401-g26

Hersteller: Rockland

Verwendungszweck: p38 Antibody

Kreuzreaktivität (Details): A BLAST analysis was used to suggest cross-reactivity with p38 from Human, Monkey, Mouse, Rat, Bovine, Rabbit, Pig, Canine, Hamster, Chicken, Sheep, and Guinea pig based on 100 % homology with the immunizing sequence.

Aufreinigung: Anti-p38 Antibody was prepared from monospecific antiserum by delipidation and defibrination.

Sterilität: Sterile filtered

Immunogen: p38 Antibody was produced from whole rabbit serum prepared by repeated immunizations raised against a 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunoprecipitation_Dilution: 1:250

Immunohistochemistry_Dilution: User Optimized

Western_Blot_Dilution: 1:1000

Kommentare:

Anti-p38 Antibody has been tested in WB, IP, IF, and IHC. Expect a band approximately ~43kDa protein corresponding to the molecular mass of p38 on SDS PAGE immunoblots. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu MAPK14

Target: MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

Andere Bezeichnung: p38

Hintergrund:

Synonyms: CSAID Binding protein 1, CSBP1, CSBP2, EXIP, MAP kinase MXI2, MAPkinase p38alpha, MAPK14, p38 ALPHA, p38 MAP kinase, p38 mitogen activated protein kinase, RK, SAPK 2A, Stress activated protein kinase 2A, 39S ribosomal protein L23, mitochondrial, L23 mitochondrial-related protein

Background: The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. This super family consists of stress activated protein kinases (SAPKs), extracellular signal-regulated kinases (ERKs), and p38 kinases, each of which forms a separate pathway. The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2α translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death. Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP. p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs. As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes.

Gene Name: MRPL23

Gen-ID: 1432

NCBI Accession: NP_001306

UniProt: Q16539

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Hepatitis C, Toll-Like Receptors Cascades, Autophagie, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteine