ATF2 Antikörper (pThr52)

Produktnummer ABIN6655068

Hersteller Produkt- Nr.: 600-401-w94

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ATF2 in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für ATF2 Antikörper (pThr52) (ABIN6655068)

Target: ATF2 (Activating Transcription Factor 2 (ATF2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-ATF2 Antikörper

Bindungsspezifität: pThr52

Hersteller Produkt- Nr.: 600-401-w94

Hersteller: Rockland

Verwendungszweck: ATF2 Phospho T52 Antibody

Kreuzreaktivität (Details): Anti-ATF2 pT52 Antibody is directed against ATF2 protein phosphorylated at T52.

Aufreinigung: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Sterilität: Sterile filtered

Immunogen: Anti-Phospho-Thr52 ATF2 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding phosphorylated Thr52 of human ATF2 conjugated to KLH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

ELISA_Dilution: 1:2,500

Western_Blot_Dilution: 1:250

Kommentare:

Anti-Phospho-Thr52 ATF2 Antibody is tested for WB. Expect a band at approximately ~74 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Preservative: None

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu ATF2

Target: ATF2 (Activating Transcription Factor 2 (ATF2))

Andere Bezeichnung: ATF2

Hintergrund:

Synonyms: Cyclic AMP-dependent transcription factor ATF-2, cAMP-dependent transcription factor ATF-2, Activating transcription factor 2, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, HB16, Histone acetyltransferase ATF2, cAMP response element-binding protein CRE-BP1

Background: The transcription factor ATF2 is a member of the ATF/CREB family of leucine zipper proteins. In response to stress stimuli, it activates a variety of gene targets that are involved in oncogenesis, and has been correlated with maintenance of a cancer cell phenotype. Inhibiting ATF2 impedes melanoma development and elicits tumor suppressor function. To act as a tumor suppressor, ATF2 must localize at the mitochondria, and phosphorylation at Thr52 by PKCε regulates this translocation. ATF2 pT52 Antibody is ideal for researchers interested in cancer research.

Gene Name: ATF2

Gen-ID: 1386

NCBI Accession: NP_001243019

UniProt: P15336

Pathways: MAPK Signalweg, RTK Signalweg, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades