AKT2 Antikörper

Produktnummer ABIN659024

Es sind 2+ Publikationen für dieses Produkt verfügbar. Der Maus Monoklonal anti-AKT2 Antikörper wird verwendet zum Nachweis von AKT2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IF und IHC (p).

Kurzübersicht für AKT2 Antikörper (ABIN659024)

Target: AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser AKT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 148CT5-4-1-4

Produktdetails anti-AKT2 Antikörper

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This AKT2 monoclonal antibody is generated from mouse immunized with AKT2 recombinant protein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:500-1:2000. WB: 1:100~500. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-AKT2 Antikörper (ABIN659024)

Sun, Zhang, Wang, Jin, Jia, Yu, Chen: "MiRNA-615-5p functions as a tumor suppressor in pancreatic ductal adenocarcinoma by targeting AKT2." in: PLoS ONE, Vol. 10, Issue 4, pp. e0119783, (2015) (PubMed).

Cui, Lin, Zuo, Zhang, Dong, Hu, Luo, Chen, Lu: "AKT2-knockdown suppressed viability with enhanced apoptosis, and attenuated chemoresistance to temozolomide of human glioblastoma cells in vitro and in vivo." in: OncoTargets and therapy, Vol. 8, pp. 1681-90, (2015) (PubMed).

Details zu AKT2

Target: AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))

Andere Bezeichnung: AKT2

Hintergrund: AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.

Molekulargewicht: 55769

Gen-ID: 208

NCBI Accession: NP_001617

UniProt: P31751

Pathways: PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, TLR Signalweg, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Hepatitis C, VEGF Signaling