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HIF1A Antikörper (AA 519-547)

Name: HIF1A Antikörper (AA 519-547)
SKU: ABIN652389
Price: 434.77 EUR
Availability: InStock

HIF1A Reaktivität: Human, Maus WB, IF, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB14548 unconjugated

Western blot analysis of lysates from Raji cell line, untreated or treated with CoCl2(0. (HIF1A Antikörper (AA 519-547))

HIF1Alpha Antibody (Center) (ABIN652389 and ABIN2841889) flow cytometric analysis of NIH-3T3 cells (right histogram) compared to a negative control cell (left histogram). (HIF1A Antikörper (AA 519-547))

FACS

Confocal immunofluorescent analysis of HIF1Alpha Antibody (Center) (ABIN652389 and ABIN2841889) with MDA-M cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (HIF1A Antikörper (AA 519-547))

HIF1Alpha Antibody (Center) (ABIN652389 and ABIN2841889) IHC analysis in formalin fixed and paraffin embedded lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. (HIF1A Antikörper (AA 519-547))

IHC (p)

5 Abbildungen

(2 Referenzen)

Produktnummer ABIN652389

Datenblatt (PDF)

Target Alle HIF1A Antikörper anzeigen

HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))
Bindungsspezifität
20

16

16

14

8

7

6

6

6

5

4

4

4

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 519-547
Reaktivität
161

92

85

23

23

20

13

11

9

8

7

6

6

5

4

2

2

2

2

2

1

1

1

1

1

1
Human, Maus
Wirt
151

53

5
Kaninchen
Passende Sekundärantikörper
Klonalität
157

52
Polyklonal
Konjugat
104

24

16

6

5

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Dieser HIF1A Antikörper ist unkonjugiert
Applikation
166

78

61

53

49

39

39

26

26

24

12

8

7

7

3

3

3

2

1

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie

B, Rat

Aufreinigung

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen

This HIF1Alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 519-547 amino acids from the Central region of human HIF1Alpha.

Klon

RB14548

Isotyp

Ig Fraction

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anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) antibody
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anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (AA 216-336) antibody
HIF1A Reaktivität: Ratte WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (AA 329-530) antibody
HIF1A Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund WB, IHC, IP, IF, ICC Wirt: Maus Monoclonal ESEE122 unconjugated

anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (AA 432-528) antibody
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anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (AA 728-757) antibody
HIF1A Reaktivität: Human, Maus WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (AA 519-547) antibody
HIF1A Reaktivität: Human, Maus WB, IHC, ELISA, IF, FACS Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

IF: 1:10~50. WB: 1:1000. WB: 1:250. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit

6 months
Li, Qu, Jin, Guo, Wang, Qi, Yang, Zhang, Li: "Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis." in: Scientific reports, Vol. 6, pp. 32131, (2018) (PubMed).

Wang, Huang, Guan, Xiao, Deng, Chen, Chen, Li, Huang, Shi: "Hypoxia-inducible factor-1alpha and MAPK co-regulate activation of hepatic stellate cells upon hypoxia stimulation." in: PLoS ONE, Vol. 8, Issue 9, pp. e74051, (2013) (PubMed).
Target

HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))

Andere Bezeichnung

HIF1Alpha (HIF1A Produkte)

Hintergrund

Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas.

Molekulargewicht

92670

Gen-ID

3091

NCBI Accession

NP_001230013, NP_001521, NP_851397

UniProt

Q16665

Pathways

Positive Regulation of Peptide Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Transition Metal Ion Homeostasis, Tube Formation, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, Warburg Effekt