TLR4 Antikörper

Produktnummer ABIN6297482

Der Maus Monoklonal anti-TLR4 Antikörper wird verwendet zum Nachweis von TLR4 in Proben von Human, Ratte, Hund, Schwein, Meerschweinchen und Affe. Er wurde validiert für FACS, IHC, IF und Func.

Kurzübersicht für TLR4 Antikörper (ABIN6297482)

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Reaktivität: Human, Ratte, Hund, Schwein, Meerschweinchen, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TLR4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF), Functional Studies (Func)

Produktdetails anti-TLR4 Antikörper

Verwendungszweck: Mouse anti-Human/Monkey/Pig/Dog/Rat/Guinea Pig TLR4 Antibody (Toll Like Receptor 4) [Sodium Azide Free]

Spezifität: Cell surface

Aufreinigung: Recombinant human protein was used as the immunogen for the TLR4 antibody.

Immunogen: Recombinant human protein was used as the immunogen for the TLR4 antibody.

Anwendungsinformationen

Applikationshinweise: Functional Activity (Order SAF formulation)
Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu TLR4

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Andere Bezeichnung: Toll-like receptor 4

Hintergrund:

Target Description: This mAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Symbol: TLR4

Gen-ID: 7099

UniProt: O00206

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteine