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Caspase 8 Antikörper (pSer347)

Der Kaninchen Polyklonal Anti-Caspase 8-Antikörper wurde für WB, IHC, ELISA, ICC und IF validiert. Er ist geeignet, Caspase 8 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN6256281

Kurzübersicht für Caspase 8 Antikörper (pSer347) (ABIN6256281)

Target

Alle Caspase 8 (CASP8) Antikörper anzeigen
Caspase 8 (CASP8)

Reaktivität

  • 167
  • 75
  • 73
  • 24
  • 16
  • 16
  • 15
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 152
  • 50
  • 6
  • 2
Kaninchen

Klonalität

  • 146
  • 63
Polyklonal

Konjugat

  • 140
  • 18
  • 14
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Caspase 8 Antikörper ist unkonjugiert

Applikation

  • 190
  • 87
  • 59
  • 50
  • 49
  • 45
  • 27
  • 27
  • 26
  • 24
  • 8
  • 4
  • 4
  • 4
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
  • Bindungsspezifität

    • 16
    • 16
    • 9
    • 9
    • 9
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer347

    Spezifität

    Phospho-Caspase 8 (Ser347) Antibody detects endogenous levels of Caspase 8 only when phosphorylated at Serine 347.

    Homologie

    Pig,Bovine,Horse,Sheep,Rabbit,Dog

    Aufreinigung

    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

    Immunogen

    A synthesized peptide derived from human Caspase 8 around the phosphorylation site of Ser347.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    Caspase 8 (CASP8)

    Andere Bezeichnung

    CASP8

    Hintergrund

    Description: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

    Gene: CASP8

    Molekulargewicht

    57kDa

    Gen-ID

    841

    UniProt

    Q14790

    Pathways

    Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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