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Caspase 9 Antikörper (Cleaved-Asp353)

This anti-Caspase 9 antibody (ABIN6254881) is a Rabbit Polyclonal antibody detecting Caspase 9 in WB, IHC, ELISA, IF, ICC. Suitable for Human, Mouse, Rat.
Produktnummer ABIN6254881

Kurzübersicht für Caspase 9 Antikörper (Cleaved-Asp353) (ABIN6254881)

Target

Alle Caspase 9 (CASP9) Antikörper anzeigen
Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Reaktivität

  • 238
  • 138
  • 109
  • 17
  • 17
  • 16
  • 4
Human, Maus, Ratte

Wirt

  • 227
  • 29
Kaninchen

Klonalität

  • 208
  • 48
Polyklonal

Konjugat

  • 143
  • 11
  • 10
  • 7
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 1
Dieser Caspase 9 Antikörper ist unkonjugiert

Applikation

  • 225
  • 84
  • 75
  • 71
  • 67
  • 67
  • 43
  • 39
  • 39
  • 33
  • 16
  • 5
  • 3
  • 3
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 28
    • 16
    • 16
    • 16
    • 16
    • 11
    • 9
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cleaved-Asp353

    Spezifität

    Cleaved-Caspase 9 (Asp353) Antibody detects endogenous levels of fragment of activated Caspase 9 resulting from cleavage adjacent to Asp353.

    Homologie

    Horse,Dog

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human Caspase 9 (Cleaved-Asp353).

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Yi, Cheng, Li, Zhao, Qu, Wang, Wang: "Protective mechanisms of purified polyphenols from pinecones of Pinus koraiensis on spleen tissues in tumor-bearing S180 mice in vivo." in: Food & function, Vol. 8, Issue 1, pp. 151-166, (2018) (PubMed).

    Yin, Meng, Zhang, Hu, Chen, Han, Wu, You, Li, Jin, Guan: "Bacillus spore-based oral carriers loading curcumin for the therapy of colon cancer." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 271, pp. 31-44, (2018) (PubMed).

  • Target

    Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

    Andere Bezeichnung

    CASP9

    Hintergrund

    Description: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).

    Gene: CASP9

    Molekulargewicht

    10 kDa

    Gen-ID

    842

    UniProt

    P55211

    Pathways

    MAPK Signalweg, RTK Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Endopeptidase Activity
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