PIK3R2 Antikörper (AA 430-470)

Produktnummer ABIN6243583

Dieses Anti-PIK3R2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PIK3R2 in WB. Geeignet für Human.

Kurzübersicht für PIK3R2 Antikörper (AA 430-470) (ABIN6243583)

Target: PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIK3R2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB48985

Produktdetails anti-PIK3R2 Antikörper

Bindungsspezifität: AA 430-470

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 430-470 amino acids from human.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu PIK3R2

Target: PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))

Andere Bezeichnung: PIK3R2

Hintergrund: Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:< a href="http://www.uniprot.org/citations/23604317" target="_blank">23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin- dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

Molekulargewicht: 81545

UniProt: O00459

Pathways: VEGF Signaling, BCR Signaling