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IRAK4 Antikörper (N-Term)

Dieses Anti-IRAK4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IRAK4 in WB und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN6243238

Kurzübersicht für IRAK4 Antikörper (N-Term) (ABIN6243238)

Target

Alle IRAK4 Antikörper anzeigen
IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reaktivität

  • 110
  • 61
  • 23
  • 15
  • 14
  • 12
  • 4
  • 3
  • 2
  • 2
  • 1
Human

Wirt

  • 103
  • 15
  • 1
Kaninchen

Klonalität

  • 100
  • 19
Polyklonal

Konjugat

  • 59
  • 6
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser IRAK4 Antikörper ist unkonjugiert

Applikation

  • 110
  • 48
  • 37
  • 26
  • 20
  • 17
  • 15
  • 10
  • 9
  • 8
  • 5
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB2347
  • Bindungsspezifität

    • 29
    • 16
    • 10
    • 8
    • 8
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 5-36, N-Term

    Homologie

    B, M

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This IRAK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-36 amino acids from the N-terminal region of human IRAK4.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Park, Kim, Yi: "Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 10, pp. 6316-27, (2009) (PubMed).

  • Target

    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

    Andere Bezeichnung

    IRAK4

    Hintergrund

    Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine-like kinase (TLK) group consists of 40 tyrosine and serine-threonine kinases such as MLK (mixed-lineage kinase), LISK (LIMK/TESK), IRAK (interleukin-1 receptor-associated kinase), Raf, RIPK (receptor-interacting protein kinase), and STRK (activin and TGF-beta receptors) families.

    Molekulargewicht

    51530

    NCBI Accession

    NP_001107654, NP_001138728, NP_001138729, NP_001138730, NP_057207

    UniProt

    Q9NWZ3

    Pathways

    NF-kappaB Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades
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