CDK8 Antikörper (C-Term)

Produktnummer ABIN6242788

Dieses Anti-CDK8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CDK8 in WB. Geeignet für Human.

Kurzübersicht für CDK8 Antikörper (C-Term) (ABIN6242788)

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB51053

Produktdetails anti-CDK8 Antikörper

Bindungsspezifität: AA 424-458, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Cdk8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 424-458 amino acids from the C-terminal region of Mouse Cdk8.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu CDK8

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Andere Bezeichnung: Cdk8

Hintergrund: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity).

Molekulargewicht: 53210

UniProt: Q8R3L8

Pathways: Zellzyklus, Regulation of Lipid Metabolism by PPARalpha