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PHLDA3 Antikörper (C-Term)

Dieses Ziege Polyklonal-Antikörper erkennt spezifisch PHLDA3 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN615985

Kurzübersicht für PHLDA3 Antikörper (C-Term) (ABIN615985)

Target

Alle PHLDA3 Antikörper anzeigen
PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))

Reaktivität

  • 23
  • 8
  • 8
  • 2
  • 2
  • 1
Human, Maus, Ratte

Wirt

  • 21
  • 1
  • 1
Ziege

Klonalität

  • 22
  • 1
Polyklonal

Konjugat

  • 13
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PHLDA3 Antikörper ist unkonjugiert

Applikation

  • 12
  • 9
  • 4
  • 2
  • 1
Western Blotting (WB), Enzyme Immunoassay (EIA)
  • Bindungsspezifität

    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term

    Sequenz

    C-RARQSLGTGT LVS

    Spezifität

    Recognizes PHLDA3 / TIH1

    Kreuzreaktivität (Details)

    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.

    Aufreinigung

    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

    Immunogen

    synthetic peptide corresponding to the C Terminus of the protein sequence of Huuman PHLDA3 (NP_036528.1). Genename: PHLDA3
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    0.5 mg/mL

    Buffer

    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target

    PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))

    Andere Bezeichnung

    PHLDA3

    Hintergrund

    P53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor. The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling.Synonyms: Pleckstrin homology-like domain family A member 3, TDAG51/Ipl homologue 1, TIH1

    Gen-ID

    23612

    NCBI Accession

    NP_036528

    UniProt

    Q9Y5J5
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