IRAK4 Antikörper (N-Term)

Produktnummer ABIN615818

Der Ziege Polyklonal anti-IRAK4 Antikörper wird verwendet zum Nachweis von IRAK4 in Proben von Human, Maus und Affe. Er wurde validiert für WB, IHC (p) und EIA.

Kurzübersicht für IRAK4 Antikörper (N-Term) (ABIN615818)

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reaktivität: Human, Maus, Affe

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser IRAK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-IRAK4 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts to the N-Terminus of Interleukin 1 Receptor-Associated Kinase 4 (IRAK4) - (peptide sequence (NKPITPSTYVRC))

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide - KLH conjugated Genename: IRAK4

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Tris buffered saline containing 0.5 % BSA as stabilizer and 0.02 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu IRAK4

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Andere Bezeichnung: IRAK4

Hintergrund: IRAK4, an IRAK type protein kinase, is a signal transducer for the immune response Toll-like receptor and interleukin-1 (IL-1) receptor signaling cascades. IRAK4 has auto- and cross-phosphorylation kinase activity and has been shown to phosphorylate and activate IRAK1. Additionally, IRAK4 interacts with IRAK1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK4 can activate NF-kappaB as well as mitogen-activated protein (MAP) kinase pathways. IRAK4 (-/-) mice are resistant to a lethal dose of lipopolysaccharide and are severely impaired in their responses to viral and bacterial challenges. At least two mRNA transcripts have been reported: 3.0- and 4.4-kb. IRAK4, also referrred to as NY-REN-64, was first identified as an antigen in a screen of renal tumors.Synonyms: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64

Gen-ID: 51135

NCBI Accession: NP_001107654

UniProt: Q9NWZ3

Pathways: NF-kappaB Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades