Cullin 2 Antikörper (AA 40-310)

Produktnummer ABIN6139249

Dieses Anti-Cullin 2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cullin 2 in WB und IF. Geeignet für Human.

Kurzübersicht für Cullin 2 Antikörper (AA 40-310) (ABIN6139249)

Target: Cullin 2 (CUL2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cullin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-Cullin 2 Antikörper

Bindungsspezifität: AA 40-310

Sequenz: LEYVERATWN DRFSDIYALC VAYPEPLGER LYTETKIFLE NHVRHLHKRV LESEEQVLVM YHRYWEEYSK GADYMDCLYR YLNTQFIKKN KLTEADLQYG YGGVDMNEPL MEIGELALDM WRKLMVEPLQ AILIRMLLRE IKNDRGGEDP NQKVIHGVIN SFVHVEQYKK KFPLKFYQEI FESPFLTETG EYYKQEASNL LQESNCSQYM EKVLGRLKDE EIRCRKYLHP SSYTKVIHEC QQRMVADHLQ FLHAECHNII RQEKKNDMAN M

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-310 of human Cullin 2 (NP_001185708.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Cullin 2

Target: Cullin 2 (CUL2)

Andere Bezeichnung: CUL2

Hintergrund: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL mediates the ubiquitination of hypoxia-inducible factor (HIF. A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component are part of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins.,CUL2,cullin-2,Cancer,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell cycle inhibitors,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,CUL2

Molekulargewicht: 86 kDa/89 kDa

Gen-ID: 8453

UniProt: Q13617

Pathways: M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interaktom