IL4 Receptor Antikörper (Tyr497)
Kurzübersicht für IL4 Receptor Antikörper (Tyr497) (ABIN5956943)
Target
Alle IL4 Receptor (IL4R) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- Tyr497
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Spezifität
- CD124,IL 4R alpha,IL-4 receptor subunit alpha,IL-4-binding protein,IL-4R subunit alpha,IL-4R-alpha,IL-4RA,IL4-BP,Il4r,IL4R nirs variant 1,IL4RA,IL4RA,Interleukin 4 receptor alpha chain,Interleukin 4 receptor,sIL4Ralpha/prot,Soluble IL-4 receptor subunit alpha,Soluble IL-4R-alpha,Soluble interleukin-4 receptor subunit alpha
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Aufreinigung
- Affinity purification
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Immunogen
- Synthesized peptide derived from human IL-4Ralpha around the non-phosphorylation site of Tyr497.
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Isotyp
- IgG
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Applikationshinweise
- WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:20000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
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Andere Bezeichnung
- IL-4Ralpha
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Hintergrund
- Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
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Molekulargewicht
- 90kDa
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Gen-ID
- 3566
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UniProt
- P24394
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Pathways
- JAK-STAT Signalweg, Positive Regulation of Immune Effector Process
Target
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