Der Maus Monoklonal Anti-AMACR-Antikörper wurde für WB, IF und IHC (p) validiert. Er ist geeignet, AMACR in Proben von Human, Maus und Ratte zu detektieren.
2 methylacyl CoA racemase,2-methylacyl-CoA racemase,Alpha methylacyl CoA racemase,Alpha-methylacyl-CoA racemase,Amacr,AMACR,AMACRD,CBAS4,EC 5.1.99.4,Macr1,RACE,RM
AMACR
Reaktivität: Human
IHC, StM
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20°C. Avoid freeze / thaw cycles.
Target
AMACR
(alpha-Methylacyl-CoA Racemase (AMACR))
Andere Bezeichnung
AMACR
Hintergrund
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.