Rekombinanter AMACR Antikörper (AA 297-394)

Produktnummer ABIN6939432

Produktdetails anti-AMACR Antikörper

Target: AMACR (alpha-Methylacyl-CoA Racemase (AMACR))

Antikörpertyp: Recombinant Antibody

Bindungsspezifität: AA 297-394

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser AMACR Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Spezifität: This antibody recognizes a protein of 42 kDa, which is identified as AMACR, also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and -oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant human AMACR protein fragment (around aa 297-394) (exact sequence is proprietary)

Klon: AMACR-2748R

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Positive Control: HEK cells. Prostate Adenocarcinoma.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu AMACR

Target: AMACR (alpha-Methylacyl-CoA Racemase (AMACR))

Andere Bezeichnung: AMACR (AMACR Produkte)

Synonyme: AMACR antikoerper, DKFZp469O1232 antikoerper, amacr antikoerper, NCU04099.1 antikoerper, MGC89832 antikoerper, AMACRD antikoerper, CBAS4 antikoerper, RACE antikoerper, RM antikoerper, Macr1 antikoerper, Da1-8 antikoerper, Marc1 antikoerper, alpha-methylacyl-CoA racemase antikoerper, PROBABLE ALPHA-METHYLACYL-COA RACEMASE MCR (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase) antikoerper, Alpha-methylacyl-CoA racemase antikoerper, alpha-methylacyl-CoA racemase L homeolog antikoerper, AMACR antikoerper, mcr antikoerper, BPSL0064 antikoerper, Maqu_2037 antikoerper, UREG_03852 antikoerper, MCYG_01809 antikoerper, amacr antikoerper, amacr.L antikoerper, MGYG_04259 antikoerper, NCU04099 antikoerper, Amacr antikoerper

Molekulargewicht: 42kDa

Gen-ID: 23600

UniProt: Q9UHK6

Pathways: Monocarboxylic Acid Catabolic Process