CD14 Antikörper (AA 16-260)
Kurzübersicht für CD14 Antikörper (AA 16-260) (ABIN5708067)
Target
Alle CD14 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 16-260
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Aufreinigung
- Antigen affinity purified
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Immunogen
- A recombinant mouse protein corresponding to amino acids S16-A260 was used as the immunogen for the CD14 antibody.
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Isotyp
- IgG
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Applikationshinweise
- Optimal dilution of the CD14 antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,ELISA (Capture, recombinant mouse protein): 0.1-0.5 μg/mL (BSA-free formulation available)
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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Lagerung
- -20 °C
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Informationen zur Lagerung
- After reconstitution, the CD14 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- CD14
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Andere Bezeichnung
- CD14
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Hintergrund
- CD14 is a single-copy gene encoding 2 protein forms: a 50- to 55 kDa glycosylphosphatidylinositol-anchored membrane protein (mCD14) and a monocyte or liver-derived soluble serum protein (sCD14) that lacks the anchor. This gene is located at bands 5q23-q31. The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns.
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UniProt
- P10810
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Pathways
- TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
Target
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