IGF1 Antikörper (pTyr1280)
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- Target Alle IGF1 Antikörper anzeigen
- IGF1 (Insulin-Like Growth Factor 1 (IGF1))
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Bindungsspezifität
- pTyr1280
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser IGF1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- This antibody detects endogenous levels of IGF-1R only when phosphorylated at tyrosine 1280.
- Aufreinigung
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- Immunogen
- IGF-1R (Phospho-Tyr1280) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Y (p) -Y-S) derived from Human IGF-1R.
- Top Product
- Discover our top product IGF1 Primärantikörper
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- Applikationshinweise
- Western Blot: 1:500~1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store antibody at -20°C for up to one year.
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- Target
- IGF1 (Insulin-Like Growth Factor 1 (IGF1))
- Andere Bezeichnung
- IGF 1 (IGF1 Produkte)
- Synonyme
- IGF-I antikoerper, IGF1A antikoerper, IGFI antikoerper, C730016P09Rik antikoerper, Igf-1 antikoerper, Igf-I antikoerper, Npt2B antikoerper, IGF-1 antikoerper, IGFIA antikoerper, IGF-IB antikoerper, igf1 antikoerper, IGF-1L antikoerper, IGF-1a antikoerper, IGF1 antikoerper, igf-1 antikoerper, igf1-A antikoerper, igf1.S antikoerper, xigf1 antikoerper, insulin like growth factor 1 antikoerper, insulin-like growth factor 1 antikoerper, insulin-like growth factor I antikoerper, insulin like growth factor 1 L homeolog antikoerper, IGF1 antikoerper, Igf1 antikoerper, LOC100136741 antikoerper, igf1 antikoerper, LOC678666 antikoerper, igf1.L antikoerper, LOC104911603 antikoerper
- Hintergrund
- This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
- Molekulargewicht
- 200, 95 kDa
- Gen-ID
- 3480
- NCBI Accession
- NP_000866
- UniProt
- P08069
- Pathways
- RTK Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation
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