FLT4 Antikörper

Produktnummer ABIN567980

Der Ratte Monoklonal Anti-FLT4-Antikörper wurde für WB validiert. Er ist geeignet, FLT4 in Proben von Maus zu detektieren.

Kurzübersicht für FLT4 Antikörper (ABIN567980)

Target: FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser FLT4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 7A3

Produktdetails anti-FLT4 Antikörper

Spezifität: This antibody will detect VEGFR-3/FLT-4 in WB in PAEC/FLT-4 cells.

Aufreinigung: Protein G Chromatography

Immunogen: Purified, insect cell-derived recombinant Mouse soluble FLT-4 (120 kDa).

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS pH 7.4 without preservatives

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FLT4

Target: FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

Andere Bezeichnung: VEGFR-3 / Flt-4

Hintergrund: Mature native mouse VEGF Receptor 3 (Flt4) is composed of a 751 amino acid residue extracellular domain, a 22 amino acid residue transmembrane domain, and a 565 amino acid residue cytoplasmic domain. Recombinant mature mouse VEGF Receptor 3/Fc is a disulfidelinked dimeric protein. Based on N-terminal sequencing, recombinant mouse VEGF Receptor 3/Fc has Met 17 at the amino-terminus. The amino acid sequence of mouse VEGF Receptor 3 is 88 % identical to human VEGF Receptor 3. VEGF Receptor 3 is a specific marker for lymphatic vessels. In adults, VEGF Receptor 3 expression is restricted to endothelial cells of the lymphatic vessels. It has also been detected on some high endothelial venules, in embryonic prelymphatic blood vessels, in some tumor blood vessels, and in certain hematopoietic and leukemia cells. The predominant role of VEGF Receptor 3 is its involvement in the development of the lymphatic vessel system. Both VEGFC and VEGFD bind and activate the receptors, VEGF Receptor 3 and VEGF Receptor 2.Synonyms: FLT4, Tyrosine-protein kinase receptor FLT4, VEGF Receptor 3, VEGFR3, Vascular endothelial growth factor receptor 3

Gen-ID: 14257

NCBI Accession: NP_032055

UniProt: P35917

Pathways: RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling