POLD1 Antikörper
Kurzübersicht für POLD1 Antikörper (ABIN567776)
Target
Alle POLD1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Spezifität
- This antibody reacts with DNA polymerase delta p125 catalytic subunit (125 kDa) by Western blotting.
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Aufreinigung
- Protein-G Agarose Chromatography of hybridoma supernatant.
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Immunogen
- Recombinant full length His-Human p125.
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Isotyp
- IgG2a
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1.0 mg/mL
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Buffer
- PBS, pH 7.2 containing 50 % Glycerol without preservatives.
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Konservierungsmittel
- Without preservative
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Handhabung
- Avoid repeated freezing and thawing.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store the antibody (in aliquots) at -20 °C.
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- POLD1 (Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))
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Andere Bezeichnung
- POLD1
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Hintergrund
- In eukaryotic cells, 3 types of DNA polymerases (pol), pol alpha, pol delta and pol epsilon function in accurate and efficient DNA replication. Pol delta is a heteromultimeric enzyme composed of a 125 kDa major catalytic subunit and three smaller accessory subunits. Pol delta requires a number of accessory molecules to exert its full activity. Proliferating cell nuclear antigen (PCNA) forms a doughnut-shaped trimer with a 35 Ä hole and works as the sliding clamp and replication factor C acts as the clamp loader to improve Pol delta processivity. Pol delta is also involved in nucleotide excision repair of DNA.Synonyms: DNA polymerase delta catalytic subunit, DNA polymerase subunit delta p125
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Gen-ID
- 5424
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NCBI Accession
- NP_002682
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UniProt
- P28340
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Pathways
- Telomere Maintenance, DNA Reparatur, DNA Replication, Chromatin Binding, Synthesis of DNA
Target
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