POLD1 Antikörper

Produktnummer ABIN567776

Der Ratte Monoklonal Anti-POLD1-Antikörper wurde für WB validiert. Er ist geeignet, POLD1 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für POLD1 Antikörper (ABIN567776)

Target: POLD1 (Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))

Reaktivität: Human, Ratte, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser POLD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 5G1

Produktdetails anti-POLD1 Antikörper

Spezifität: This antibody reacts with DNA polymerase delta p125 catalytic subunit (125 kDa) by Western blotting.

Aufreinigung: Protein-G Agarose Chromatography of hybridoma supernatant.

Immunogen: Recombinant full length His-Human p125.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu POLD1

Target: POLD1 (Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))

Andere Bezeichnung: POLD1

Hintergrund: In eukaryotic cells, 3 types of DNA polymerases (pol), pol alpha, pol delta and pol epsilon function in accurate and efficient DNA replication. Pol delta is a heteromultimeric enzyme composed of a 125 kDa major catalytic subunit and three smaller accessory subunits. Pol delta requires a number of accessory molecules to exert its full activity. Proliferating cell nuclear antigen (PCNA) forms a doughnut-shaped trimer with a 35 Ä hole and works as the sliding clamp and replication factor C acts as the clamp loader to improve Pol delta processivity. Pol delta is also involved in nucleotide excision repair of DNA.Synonyms: DNA polymerase delta catalytic subunit, DNA polymerase subunit delta p125

Gen-ID: 5424

NCBI Accession: NP_002682

UniProt: P28340

Pathways: Telomere Maintenance, DNA Reparatur, DNA Replication, Chromatin Binding, Synthesis of DNA