Caspase 8 Antikörper (Biotin)
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- Target Alle Caspase 8 (CASP8) Antikörper anzeigen
- Caspase 8 (CASP8)
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Caspase 8 Antikörper ist konjugiert mit Biotin
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- Recombinant human Caspase 8 Protein
- Klon
- 4G12
- Isotyp
- IgG
- Top Product
- Discover our top product CASP8 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
IHC-P 1:200-400 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C for 12 months.
- Haltbarkeit
- 12 months
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- Target
- Caspase 8 (CASP8)
- Andere Bezeichnung
- Caspase 8 (CASP8 Produkte)
- Synonyme
- casp8-A antikoerper, xCaspase-8 antikoerper, casp8 antikoerper, CASP8 antikoerper, CASP-8 antikoerper, FLICE antikoerper, MACH antikoerper, Mch5 antikoerper, ALPS2B antikoerper, CAP4 antikoerper, Casp-8 antikoerper, MCH5 antikoerper, caspase-8 antikoerper, zgc:92075 antikoerper, caspase 8 L homeolog antikoerper, death related ced-3/Nedd2-like protein antikoerper, caspase 8 antikoerper, caspase-8 antikoerper, caspase-8-like antikoerper, caspase 8, apoptosis-related cysteine peptidase antikoerper, casp8.L antikoerper, LOC661095 antikoerper, CASP8 antikoerper, LOC5563818 antikoerper, casp8 antikoerper, LOC100222284 antikoerper, Casp8 antikoerper
- Hintergrund
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Synonyms: Caspase-8 subunit p10, ALPS2B, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein, Apoptosis related cysteine peptidase, Apoptotic cysteine protease, Apoptotic protease Mch 5, Apoptotic protease Mch-5, Apoptotic protease Mch5, CAP 4, CAP4, CASP 8, CASP-8, Caspase-8, Caspase8, CASP8, CASP8_HUMAN, Caspase8, Caspase 8 apoptosis related cysteine peptidase, Caspase8, CED 3, FADD homologous ICE/CED 3 like protease, FADD Homologous ICE/CED3 Like Protease, FADD Like ICE antibody FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, FLJ17672, ICE like apoptotic protease 5, ICE-like apoptotic protease 5, MACH alpha 1/2/3 protein, MACH antibody MACH beta 1/2/3/4 protein antibody MCH 5, MCH5.
Background: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
- Gen-ID
- 841
- UniProt
- Q14790
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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