PRKACA Antikörper (C-Term)

Produktnummer ABIN5672620

Der Kaninchen-Polyklonal Anti-PRKACA-Antikörper wurde für WB validiert. Er ist geeignet zum Nachweis von PRKACA in Proben aus Human. }

Kurzübersicht für PRKACA Antikörper (C-Term) (ABIN5672620)

Target: PRKACA (Protein Kinase A, alpha (PRKACA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKACA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PRKACA Antikörper

Bindungsspezifität: C-Term

Sequenz: ATTDWIAIYQ RKVEAPFIPK FKGPGDTSNF DDYEEEEIRV SINEKCGKEF

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of Human PRKACA

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PRKACA

Target: PRKACA (Protein Kinase A, alpha (PRKACA))

Andere Bezeichnung: PRKACA

Hintergrund: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

Alias Symbols: PKACA, PPNAD4

Protein Size: 41

Molekulargewicht: 351 kDa

Gen-ID: 5566

NCBI Accession: NM_001304349, NP_001291278

UniProt: P17612

Pathways: NF-kappaB Signalweg, Hedgehog Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion