CD36 Antikörper

Produktnummer ABIN5541988

Dieses Anti-CD36-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD36 in FACS, IF, IHC (fro) und ICC. Geeignet für Human.

Kurzübersicht für CD36 Antikörper (ABIN5541988)

Target: CD36

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD36 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Klon: 185-1G2

Produktdetails anti-CD36 Antikörper

Spezifität: The Monoclonal antibody 185-1G2 recognizes an epitope between amino acids 155-183 on the CD36 Molecule.

Aufreinigung: Purified

Immunogen: Derived by fusion of NS1 mouse myeloma cells with spleen cells from BALB/c mice immunized with stimulated Human leucocytes.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 1/100-1/200. The antibody 185-1G2 can be used for CD36 cell identification, quantification and isolation using flow cytometric methods. Immunocytochemistry. Immunohistochemistry on Frozen Sections. Functional Assay: The antibody has also been reported to bind to a site of CD36 that inhibits CD36 function. Please request a Sodium Azide Free antibody format.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Buffer System: PBS Preservatives: 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD36

Target: CD36

Andere Bezeichnung: cd36

Hintergrund: The CD36 Molecule is an 88 kDa transmembrane glycoprotein, which is a member of the class B scavenger receptor family of proteins. Alternative names for CD36 include fatty acid translocase (FAT), platelet glycoprotein 4, platelet glycoprotein IIIb and thrombospondin receptor. CD36 is a pattern recognition receptor that is expressed on a wide variety of cells including monocytes, macrophages, platelets, adipocytes, erythrocyte precursors, activated keratinocytes and some endothelial and epithelial cells. Studies suggest that CD36 has multiple cellular functions and binds to a diverse array of ligands including thrombospondin, modified low-density lipoproteins (LDL), anionic phospholipids and long chain fatty acids. As a scavenger receptor, CD36 plays a key role in mediating the uptake of oxidized LDL by macrophages, the formation of foam cells and the development of atherosclerosis. CD36 is also reported to function as negative regulator of angiogenesis, as a cell adhesion molecule involved in platelet adhesion and aggregation, and as a scavenger receptor in the clearance of apoptotic cells and photoreceptor rod outer segments. Furthermore, CD36 is reported to bind toPlasmodium falciparum infected erythrocytes and may play an important role in the pathogenesis of malaria and sickle cell disease.

UniProt: P16671

Pathways: TLR Signalweg, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteine